Across the U.S. cannabis market, certain strains have surged in popularity, consistently topping sales charts in dispensaries nationwide. We’ll review the most sought-after cultivars, highlight the standout brands behind them, and explore where shoppers can pick them up.

Most Popular Strains Across the Nation

At the forefront of consumer favorites are Wedding Cake and Lemon Cherry Gelato. Wedding Cake stands out for its soothing indica-dominant profile and dessert-like flavor that offers deep relaxation. Lemon Cherry Gelato, meanwhile, balances bold, tart-berry terpenes and an uplifting hybrid high, making it a versatile pick. Other heavyweights include RS11 (Rainbow Sherbet), Zoap, Permanent Marker, Tangie, Runtz, and Apple Fritter—all praised for their potency, unique aromas, and smooth, intriguing effects.

State-Specific Standouts

Sales trends vary by state. In California, Blue Dream reigned supreme in 2024, generating a staggering $25.9 million in flower sales and topping pre-roll and vape categories as well. Across various states, Wedding Cake consistently ranks as a top seller in Washington and Arizona, while Blue Dream remains king in California and Connecticut. In Michigan, local favorites like Gelato continue to sell strongly.

Regional Favorites in Michigan

At Heads Dispensary in Adrian, Michigan, shoppers are increasingly gravitating toward hybrid strains such as Orangutan, Platinum Lemon Cherry Gelato, and Animal Face for their flavor complexity and reliable effects. For those after something more relaxing, Lemon Venom, an indica-dominant strain known for its zesty citrus flavor and calming potency, is also gaining traction.

Cutting-Edge Cultivars

Emerging hybrids like Zoap—a euphoric blend with playful, relaxed effects—are rising fast on national charts. Meanwhile, strains such as Godfather OG, boasting an ultra-potent 34% THC and recognized for strong stress-relief and anti-inflammatory effects, are turning heads for their raw power.

Why These Strains Stand Out

What ties all these cultivars together? High THC content is a clear draw—RS11, Zoap, and Godfather OG boast THC percentages in the upper 20s and beyond. Flavor plays a critical role too: tart-berry notes, candy aromas, citrus tang—unique terpene profiles differentiate these strains in a crowded market. Finally, consistency and availability—many of these strains are widely distributed across dispensaries, meeting demand without lag.

Where to Find Them

• Wedding Cake and Lemon Cherry Gelato are staples at many dispensaries nationwide—check locally via Leafly or Headset listings.
• In California, Blue Dream remains a bestseller across flower, pre-rolls, and vape pens—widely available in major retail chains and independent shops.
• At Heads Dispensary in Adrian, Michigan, shoppers can find Orangutan, Animal Face, and Lemon Venom among the top-selling strains.

This snapshot of today’s top-selling cannabis strains offers an engaging glimpse into what’s capturing consumer attention—whether you’re after flavor-forward hybrids, potent classics, or rising stars.